The CSE/H2S pathway is an important therapeutic target for protection against atherosclerosis, as decreased endogenous H2S accelerates vascular damage.
Endogenously synthesized H2S protects vascular tissues from atherogenic damage by reducing vessel intimal proliferation and inhibiting adhesion molecule expression. Decreased endogenous H2S production predisposes the animals to vascular remodeling and early development of atherosclerosis. The CSE/H2S pathway is an important therapeutic target for protection against atherosclerosis.
Balasubramanian et al. (Fri,) studied this question.