What question did this study set out to answer?

To investigate impaired adipose anabolism in pancreatic cancer cachexia and evaluate the role of HuR inhibition.

March 21, 2026Journal of Cachexia Sarcopenia and Muscle0 citationsOpen Access

Impaired Adipose Anabolism in Pancreatic Cancer Cachexia Is Reversed by HuR Inhibition

PAPaige C. Arneson‐WissinkOregon Health & Science University KPKatherine R. PelzOregon Health & Science University BWBeth L. WorleyOregon Health & Science University

Key Points

To investigate impaired adipose anabolism in pancreatic cancer cachexia and evaluate the role of HuR inhibition.
Used 3T3-L1 adipocytes treated with PDAC conditioned media
Studied PDAC mice to analyze adipose tissue responses
Applied small molecule KH-3 to disrupt HuR binding
Deficient adipose anabolism was observed in treated 3T3-L1 cells and PDAC mice
Inhibition of HuR using KH-3 restored adipose anabolism
Suggests HuR as a target for improving lipid content in cancer cachexia

Abstract

Our work highlights deficient adipose anabolism as a driver of reduced lipid content in 3T3-L1 adipocytes treated with PDAC conditioned media and PDAC mice. The small molecule KH-3, which disrupts HuR binding, restored adipose anabolism in PDAC mice. This highlights HuR as a potentially targetable regulatory node for adipose anabolism in cancer cachexia.

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