Aquaporin 1 promotes proliferation and migration of tumor by up-regulating claudin-1 expression in colon cancer | Synapse
March 22, 2026Open Access
Aquaporin 1 promotes proliferation and migration of tumor by up-regulating claudin-1 expression in colon cancer
Key Points
The research aims to investigate the role of aquaporin 1 in enhancing colon cancer cell proliferation and migration through claudin-1 expression.
Analyzed aquaporin 1 expression levels in colon cancer samples
Evaluated the correlation between aquaporin 1 and claudin-1
Performed cellular assays to assess proliferation and migration rates
AQP1 levels were higher in colon cancer tissues compared to normal tissues
Increased AQP1 expression was associated with elevated claudin-1 levels
Cell assays indicated that higher AQP1 led to increased cell proliferation and migration.
Abstract
AQP1 correlates with unfavorable prognosis in colon cancer and potentially enhances the proliferation and migration of colon cancer by up-regulating claudin-1 expression.