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March 23, 2026Open Access

The therapeutic effects of the VEGF decoy receptor fusion protein VEGF-Grab in chronic inflammatory diseases

YLYoungeun LeeKorea Advanced Institute of Science and Technology HLHee-Young LeeCatholic University of Korea HLHye Seong LimKorea Research Institute of Bioscience and Biotechnology

Key Points

The central aim is to evaluate the therapeutic effects of the VEGF decoy receptor fusion protein VEGF-Grab in chronic inflammatory diseases.
Assess VEGF-Grab's biological activity in models of chronic inflammation.
Evaluate its safety and efficacy through in vitro and in vivo experiments.
Analyze inflammatory markers and disease progression in treated subjects.
VEGF-Grab significantly reduced inflammatory markers compared to control.
Improved clinical outcomes were observed in chronic inflammation models after treatment.
Safety assessments indicated a favorable profile with no major adverse effects.

Abstract

This study was supported by grants funded by the National Research Foundation of Korea (RS-2024-00442793 to W.U.K.), and Biomlogic/GenoFocus and Panolos Biosciences (to S.H.L.).

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Cite This Study

Lee et al. (Thu,) studied this question.

synapsesocial.com/papers/69c0ddb8fddb9876e79c1124 https://doi.org/https://doi.org/10.1016/j.ebiom.2026.106216

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