β-Hydroxybutyrate upregulates hepatic histone β-hydroxybutyrylation modification, promotes the expression of PPARα, and alleviates the hepatic steatosis in MASLD

Key Points

• This research aims to explore how β-hydroxybutyrate influences liver lipid regulation and histone modifications in MASLD.
• Evaluated the impact of β-hydroxybutyrate on liver cells
• Assessed the expression levels of PPARα and related genes
• Analyzed histone modifications in hepatocytes.
• β-Hydroxybutyrate significantly promotes the expression of PPARα
• Increased lipid oxidation-related gene expression was observed
• Marked reduction in lipid accumulation in liver tissue was noted.