What question did this study set out to answer?

The research aims to explore how short-term radiation-induced toxicity influences oncological outcomes in high-risk prostate cancer.

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March 25, 2026Open Access

Association between short-term radiation-induced toxicity and oncological outcomes in high-risk prostate cancer: a retrospective single-centre cohort study

Key Points

The research aims to explore how short-term radiation-induced toxicity influences oncological outcomes in high-risk prostate cancer.
Retrospective cohort design
Assessment of early grade ≥ 2 genitourinary (GU) and gastrointestinal (GI) toxicity
Evaluation of freedom from biochemical recurrence (FFBR) and metastasis-free survival (MFS) after treatments
GU-toxicity correlated with worse FFBR and MFS following external beam radiation therapy (EBRT) alone
No association found between GU-toxicity and outcomes after EBRT combined with brachytherapy (EBRT-BT)
GI toxicity showed no significant impact on oncological outcomes

Abstract

Early grade ≥ 2 GU-toxicity was linked to worse FFBR and MFS after EBRT alone, whereas no such association was seen after EBRT-BT. GI toxicity showed no prognostic impact. These exploratory findings warrant validation in larger studies addressing interactions between patient-, tumour- and treatment-related factors.

Association between short-term radiation-induced toxicity and oncological outcomes in high-risk prostate cancer: a retrospective single-centre cohort study

Key Points

Abstract

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