Outstanding presence of New Delhi metallo-beta-lactamase in carbapenem-resistant Enterobacterales and exceptionally potent in vitro activity of cefiderocol and aztreonam-avibactam emphasises their immediate access in India

Key Points

• The study aims to assess the prevalence of the blaNDM gene in carbapenem-resistant Enterobacterales (CRE) and the effectiveness of cefiderocol and aztreonam-avibactam.
• Analyzed clinical isolates of carbapenem-resistant Enterobacterales (CRE) for the presence of the blaNDM gene.
• Evaluated the in vitro activity of cefiderocol and aztreonam-avibactam against these isolates.
• Discovered a high prevalence of the blaNDM gene among CRE clinical isolates.
• Cefiderocol and aztreonam-avibactam showed effectiveness against 98% of tested CRE isolates.