A dual-site fluorescent probe for tracing the interaction between ATP and NE in neuroinflammation

Key Points

• This research aims to explore the interactive roles of ATP and norepinephrine in neuroinflammation using a novel fluorescent probe.
• Developed a dual-site fluorescent probe to visualize neurotransmitter release.
• Utilized a neuroinflammatory model for testing.
• Monitored the exocytosis of ATP and norepinephrine without cross-coloring.
• ATP promotes norepinephrine exocytosis during neuroinflammation.
• Visualization allows for real-time tracking of both neurotransmitters.
• The probe provides a new tool for understanding co-transmission in inflammatory responses.