Abstract Background: This study aimed to evaluate and compare the effects of low-level laser therapy (LLLT) and platelet-rich fibrin (PRF) on orthodontic tooth movement (OTM), focussing on canine retraction and levels of inflammatory cytokine interleukin-1 beta (IL-1β). Methods: Forty sites requiring canine retraction were randomly assigned to two groups: LLLT and PRF. Laser treatment was performed at a wavelength of 940 nm with a power output of 200 mW, and PRF was prepared by centrifugation. Canine retraction rates were measured over an eight-week period, and gingival crevicular fluid (GCF) samples were collected to assess IL-1β levels. Results: The mean canine retraction rate was 4.828 mm in the LLLT group and 4.013 mm in the PRF group, indicating that LLLT significantly accelerated tooth movement compared to PRF. Although IL-1β levels were higher in the LLLT group at T2 ( P < 0.05), no significant differences were observed between the groups at other time points. This study found that both treatments were effective in promoting OTM without adversely affecting periodontal health. Conclusions: Both LLLT and PRF can be used therapeutically to enhance OTM; LLLT demonstrates a superior rate of canine retraction. This study suggests that while IL-1β levels provide insights into inflammatory responses during tooth movement, the presence of additional growth factors in PRF may also influence outcomes.
Priya et al. (Wed,) studied this question.