What question did this study set out to answer?

This research aims to assess the impact of pre-existing resistance mutations on the effectiveness of dolutegravir in treatment-naïve patients.

March 26, 2026

Baseline resistance mutations and virological response to dolutegravir in treatment-naïve patients: a multicentre NGS study

Key Points

This research aims to assess the impact of pre-existing resistance mutations on the effectiveness of dolutegravir in treatment-naïve patients.
Multicentre study design
Utilization of next-generation sequencing (NGS)
Focus on treatment-naïve individuals
Assessment of baseline resistance mutations and virological outcomes
Pre-existing IN and RT resistance mutations did not significantly affect virological efficacy of dolutegravir
Support for the high resistance barrier of dolutegravir
Indication that baseline resistance testing may be unnecessary for treatment-naïve patients

Abstract

Our findings indicate that pre-existing IN and RT DRM, including low-abundance and secondary/polymorphic variants, did not compromise the virological efficacy of dolutegravir-based triple therapy in ART-naïve individuals, supporting the high resistance barrier of dolutegravir and the lack of need for baseline resistance testing.

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Cite This Study

Inciarte et al. (Wed,) studied this question.

synapsesocial.com/papers/69c4cc85fdc3bde448917e48 https://doi.org/https://doi.org/10.1093/jac/dkag080

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