Stage-dependent gut microbiome and functional signatures across the liver disease spectrum: an integrative multicohort study.

Key Points

• The study aims to understand how the gut microbiome changes at different stages of liver diseases and its potential diagnostic value.
• Large-scale analysis across multiple cohorts
• Assessment of gut microbiome composition and function
• Development of potential microbiome-based diagnostic markers
• Identified distinct ecological remodelling of gut microbiome at different liver disease stages
• Highlighted microbiome signatures as potential non-invasive biomarkers for diagnosis
• Suggests improved prognostic risk stratification based on microbiome findings