Inflammation and oxidative stress are central mediators of acute and chronic diseases. Here, we present a chitosan-stabilized silver–nimesulide coordination complex engineered to enhance anti-inflammatory and redox-modulating performance while enabling controlled drug release. Spectroscopic and crystallographic analyses confirmed the formation of an Ag–NMS coordination core embedded within a polymeric chitosan matrix. The biocomposite significantly reduced carrageenan-induced edema, MPO activity, and lipid peroxidation, while modulating thiol-dependent redox responses. These findings demonstrate that coordination-driven polymeric stabilization improves the therapeutic profile of nimesulide and supports further preclinical investigation of this multifunctional biocomposite.
Narvaez et al. (Tue,) studied this question.
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