Chemical Similarity Methods- A Tutorial Review

Key Points

• The central aim is to evaluate and compare four distinct methods for measuring chemical similarity.
• Review of four chemical similarity methods
• Analysis of fingerprint-based similarity
• Assessment of physiochemical property descriptors
• Examination of virtual screening techniques
• Explanation of SMILE-based searches
• Identified four key methods for studying chemical similarity
• Discussed advantages and limitations of each method
• Highlighted the relevance of these methods in chemical research