What question did this study set out to answer?

To investigate how Yiqi Qingre Gao influences podocyte injury through autophagy and NLRP3 inflammasome crosstalk.

March 28, 2026Open Access

WCN26-2245 Yiqi Qingre Gao alleviates podocyte injury via regulating autophagy-NLRP3 inflammasome crosstalk

Key Points

To investigate how Yiqi Qingre Gao influences podocyte injury through autophagy and NLRP3 inflammasome crosstalk.
Utilized primary myofibroblasts from CKD patients' urine
Examined the effects of HDAC inhibition on myofibroblast differentiation
Assessed EPO-producing capability and ECM production levels
HDAC inhibition promoted the dedifferentiation of renal myofibroblasts into fibroblasts
Enhanced EPO-producing capability was restored
Induced apoptosis in activated myofibroblasts, reducing ECM production

Abstract

inhibition restored the EPO-producing capability and fibroblastic signatures (including CD73 expression, Figure) to the primary myofibroblasts obtained from the urine of a patient with CKD.Conclusion: HDAC inhibition promotes the dedifferentiation of renal myofibroblasts into fibroblasts and induces apoptosis in activated, highly ECM-producing myofibroblasts.This strategy offers a novel therapeutic approach that could potentially not only suppress renal fibrosis but also ameliorate associated tubular damage and EPO deficiency.

Bookmark

View Full Paper

Cite This Study

Wang et al. (Wed,) studied this question.

synapsesocial.com/papers/69c76fff8bbfbc51511e0562 https://doi.org/https://doi.org/10.1016/j.ekir.2026.105357

Bookmark

View Full Paper