Characterising the chemical composition of Halogeton sativus (L.) Moq. essential oil and its AcOEt (HSAE) and n-BuOH (HSBE) fractions aimed to evaluate their anti-inflammatory, antioxidant, and photoprotective properties. The main volatile components were tetracosane (14.55%), pentacosane (18.09%), and hexahydrofarnesylacetone (46.45%). Key phenolic constituents included gentisic, salicylic, chlorogenic, caffeic, and p-coumaric acids, with quercetin being the predominant compound in HSAE (33.62 mg/g). Antioxidant tests (DPPH•, ABTS•+, FRAP, and phenanthroline) indicated that HSAE demonstrated higher capacity (IC50 = 7.90 ± 0.15 μg/mL, IC50 = 13.36 ± 0.01 μg/mL, A0.5 = 16.14 ± 0.09 μg/mL, and A0.5 = 16.14 ± 0.09 μg/mL, respectively). Both HSBE and HSAE exhibited photoprotective efficacy with an SPF value around 33.9. Their anti-inflammatory potential was significant, with IC50 values of 35.16 ± 0.93 and 78.15 ± 0.13 µg/mL, respectively. These findings suggest the possible applications of H. sativus for reducing inflammation, oxidative stress, and UV damage protection.
Kebbi et al. (Wed,) studied this question.