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The research examines the rise in cases of metformin-associated lactic acidosis following the COVID-19 pandemic in hospitalized patients.

March 28, 2026Kidney International Reports0 citationsOpen Access

Wcn26-6976 Increase in Metformin–associated Lactic Acidosis in a Tertiary Croatian Hospital After the Covid Pandemic

KAKarmela AltabasSisters of Charity Hospital VVVesna VucelićSisters of Charity Hospital PGPetar GezmanSisters of Charity Hospital

Key Points

The research examines the rise in cases of metformin-associated lactic acidosis following the COVID-19 pandemic in hospitalized patients.
Analyzed patient records from a Croatian tertiary hospital
Examined lactic acidosis incidents linked to metformin usage
Considered impacts of COVID-19 on hospitalization and treatment protocols
Notable increase in cases of lactic acidosis among metformin users
Interventions and treatment strategies had to be adjusted
Highlighting a potential correlation with the COVID-19 pandemic impact

Abstract

84; 95% CI 0.80-0.88)and hospitalization (aHR 0.80; 95% CI 0.72-0.88)compared to those vaccinated with BNT162b2.Conclusion: A third mRNA COVID-19 vaccine dose substantially enhanced protection against SARS-CoV-2 infection and severe outcomes in HD patients during the Omicron period, with the mRNA-1273 vaccine demonstrating superior effectiveness compared to BNT162b2.Booster vaccination strategies are essential to reduce severe COVID-19 outcomes in this high-risk population.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.

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