Seeking the Mechanism for Reversal of Enhanced Insulin Sensitivity after Acute Exercise

Key Points

• The study aims to explore how high-carbohydrate intake postexercise affects the reversal of enhanced insulin sensitivity.
• Examined the effects of a single endurance exercise session on insulin-stimulated glucose uptake.
• Analyzed the impact of a high-carbohydrate diet administered after exercise.
• Hypothesized the role of the hexosamine biosynthetic pathway in glucose flux postexercise.
• Acute exercise significantly elevated insulin-stimulated glucose uptake in skeletal muscle.
• Refeeding with a high-carb diet accelerated the reversal of this enhanced glucose uptake.
• Increased glucose flux through the hexosamine pathway was linked to this reversal.