Streamlined cofactor recycling with formate for chemo-enzymatic synthesis

Key Points

• The aim is to enhance cofactor recycling through efficient NADH regeneration using a novel catalyst.
• Development of COF‑OH‑Rh catalyst
• Utilization of formate for NADH regeneration
• Comparison of hydrogen-radical pathway to classical hydride-transfer route
• Achieved NADH regeneration yield of 87%
• Hydrogen-radical pathway demonstrated higher efficiency than classical methods