Exercise echocardiography identifies symptomatic HCM patients with obstruction missed at rest who derive similar benefits from mavacamten as those with resting or Valsalva-provoked obstruction.
Does mavacamten provide similar treatment benefits in symptomatic HCM patients requiring exercise echocardiography for LVOTO documentation compared to those with resting or Valsalva-provoked obstruction?
Exercise echocardiography is essential for identifying symptomatic HCM patients with significant LVOTO who are eligible for and benefit from mavacamten, as they do not have a milder phenotype than those with resting obstruction.
Absolute Event Rate: 0% vs 0%
Patients requiring exercise echocardiography to document qualifying LVOTO do not exhibit a milder disease phenotype and derive similar treatment benefits from mavacamten compared to those with resting or Valsalva-provoked obstruction. Exercise echocardiography identifies a substantial proportion of symptomatic HCM patients with significant LVOTO missed by resting assessment and is essential for guiding treatment eligibility.
Erzeel et al. (Mon,) reported a other. Exercise echocardiography identifies symptomatic HCM patients with obstruction missed at rest who derive similar benefits from mavacamten as those with resting or Valsalva-provoked obstruction.