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March 30, 2026The Journal of Infectious Diseases3 citations

Divergent pathogenesis of two Chinese Crimean–Congo hemorrhagic fever viruses in cynomolgus macaques

JRJuhong RaoWuhan Institute of Virology YYYanfeng YaoWuhan Institute of Virology XHXue HuWuhan Institute of Virology

Key Points

To investigate the divergent pathogenesis of two Chinese Crimean–Congo hemorrhagic fever viruses in cynomolgus macaques.
Utilized cynomolgus macaques as a model for the disease.
Assessed clinical, virological, and pathological outcomes after infection with virus isolates.
Evaluated the effectiveness of potential medical countermeasures against the viruses.
Chinese virus isolates exhibited distinct clinical phenotypes in macaques.
Differences in virological behavior were observed between the two viruses.
Pathological assessments confirmed distinct features associated with each virus.

Abstract

These findings demonstrate that Chinese isolates exhibit distinct clinical, virological, and pathological phenotypes in cynomolgus macaques, underscoring the value of this model for recapitulating aspects of CCHF disease, for pathogenesis research, and for evaluating medical countermeasures.

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