Methodological Challenges of Emulating a Target Trial to Assess Effectiveness of Timing of PCSK9 Inhibitor Treatment Initiation Post Myocardial Infarction

Key Points

• The research aims to address the methodological challenges of evaluating treatment timing for PCSK9 inhibitors after a heart attack.
• Discussion of the clone-censor-weight method
• Identification of challenges in small, imbalanced groups
• Exploration of practical guidance for new treatments
• Highlights difficulties in evaluating treatment effectiveness
• Suggests improvements for emulation of target trials