Intraoperative Photodynamic Diagnosis Using 5-Aminolevulinic Acid Combined with Talaporfin Sodium Photodynamic Therapy for Recurrent High Grade Glioma—Adverse Event and Counterpart—

Key Points

• This research aims to evaluate the safety and adverse events of using 5-ALA and TS together in glioma surgery.
• Examined the combination of 5-ALA for diagnosis and TS for therapy during surgery.
• Monitored adverse events associated with 5-ALA and TS usage.
• Conducted surgeries on patients with recurrent high-grade glioma.
• Combination of 5-ALA-PDD and TS-PDT did not increase phototoxicity risk.
• No severe adverse events were reported during surgical application.
• The method is deemed safe for improving surgical outcomes.