4-OI improves mitochondria-associated endoplasmic reticulum membrane dysfunction by regulating MFN2 through Nrf2 transcription and alleviates airway inflammation in asthma exposed to PM2.5 early in life

Key Points

• The study aims to explore how 4-OI influences mitochondrial health and airway inflammation in asthma caused by PM2.5 exposure.
• Evaluated the effect of 4-OI on mitochondrial-associated endoplasmic reticulum dysfunction.
• Assessed changes in MFN2 levels and Nrf2 transcription activity.
• Analyzed airway inflammation markers in asthmatic models exposed to PM2.5.
• 4-OI significantly improved mitochondrial-associated endoplasmic reticulum function.
• There was an increase in MFN2 levels linked to enhanced Nrf2 transcription.
• Airway inflammation markers were reduced in the presence of 4-OI.