ZFP36L1 promotes non‐small cell lung cancer progression under hypoxia by modulating CXCL9:SPP1 polarity: A single‐cell transcriptomic study

Key Points

• This research investigates how ZFP36L1 influences cancer progression in non-small cell lung cancer during low oxygen conditions.
• Utilized single-cell transcriptomic analysis to examine gene expression changes
• Focused on the relationship between ZFP36L1, CXCL9, and SPP1 in a cancer context
• Analyzed the effects of hypoxia on macrophage-related signaling pathways.
• ZFP36L1 transcriptionally regulates SPP1 under hypoxia
• Reduction in macrophage CXCL9:SPP1 ratio was observed
• Association between low oxygen levels and increased NSCLC malignancy was established.