What question did this study set out to answer?

This research aims to examine the perinatal outcomes of twin pregnancies affected by early twin-to-twin transfusion syndrome (TTTS) and the influence of diagnostic timing.

April 1, 2026Open Access

Perinatal outcomes of twin pregnancies complicated by early twin‐to‐twin transfusion syndrome treated with fetoscopic laser surgery

Key Points

This research aims to examine the perinatal outcomes of twin pregnancies affected by early twin-to-twin transfusion syndrome (TTTS) and the influence of diagnostic timing.
Comparison of cases diagnosed at different Quintero Stages (I-II vs III-IV)
Analysis of survival rates based on timing of TTTS diagnosis (≤ 16 weeks vs > 16 weeks)
Consideration of revisions to current diagnostic criteria
Most early-TTTS cases diagnosed at Quintero Stage III
No significant difference in survival rates between early and late diagnosis in most cases
Higher survival rates for cases diagnosed at Stages I-II when diagnosed ≤ 16 weeks

Abstract

The diagnosis and management of TTTS ≤ 18 weeks are more complex than those of TTTS diagnosed > 18 weeks. More early-TTTS cases were diagnosed at Quintero Stage III, but the overall survival rate was not significantly different between cases diagnosed at Quintero Stages I-II vs Stages III-IV, except when the diagnosis was made ≤ 16 weeks, in which case the survival rate was higher among cases diagnosed at Stages I-II. Revisions to the diagnostic criteria for early TTTS should be considered. © 2026 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.

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Cite This Study

Sileo et al. (Mon,) studied this question.

synapsesocial.com/papers/69ccb71716edfba7beb88e16 https://doi.org/https://doi.org/10.1002/uog.70196

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