What question did this study set out to answer?

This research investigates the impact of male sex on outcomes in COPD patients with pulmonary hypertension.

April 1, 2026Open Access

Male Sex Is Associated With Severe Pulmonary Hypertension and Worse Outcome in Chronic Obstructive Pulmonary Disease Patients Referred for Right Heart Catheterization

Key Points

This research investigates the impact of male sex on outcomes in COPD patients with pulmonary hypertension.
Analyzed data from 171 patients in the GRAPHIC registry
Focused on sex differences in COPD patients
Assessed mortality risk relative to pulmonary hypertension severity
Male sex is independently linked to higher mortality risk
Patients had similar comorbidities and airflow obstruction
Increased rates of severe pulmonary hypertension contribute to worse outcomes

Abstract

ABSTRACT Sex differences in COPD patients with concomitant pulmonary hypertension remain unexplored. Analyzing 171 patients from the GRAPHIC registry in Graz, Austria, we found that male sex was independently associated with increased mortality risk, despite comparable comorbidities and airflow obstruction, which may be explained by the increased rate of severe PH.

Male Sex Is Associated With Severe Pulmonary Hypertension and Worse Outcome in Chronic Obstructive Pulmonary Disease Patients Referred for Right Heart Catheterization

Key Points

Abstract

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