A higher 123I-BMIPP SPECT washout rate was significantly associated with an increased incidence of major adverse cardiac events (OR 1.13) in patients with vasospastic angina.
Cohort (n=104)
No
Does a higher 123I-BMIPP-SPECT washout rate predict major adverse cardiac events in patients with vasospastic angina?
In patients with vasospastic angina, a higher washout rate on 123I-BMIPP-SPECT is associated with a significantly increased risk of major adverse cardiac events, suggesting its utility for early risk stratification.
Effect estimate: OR 1.13 (95% CI 1.01-1.26)
p-value: p=0.03
Introduction: 123I-Betamethyl-p-iodophenyl-pentadecanoic acid single-photon emission computed tomography (123I-BMIPP-SPECT) is a myocardial fatty acid metabolism imaging technique that has been found to be effective in identifying high-risk patients with known ischemic heart disease. However, its efficacy in assessing vasospastic angina (VA) remains unclear. Hence, in this current study, we aimed to evaluate the association between 123I-BMIPP-SPECT parameters and the clinical incidence of cardiac risk in VA. Methods: Among the 71 consecutive patients admitted to our hospital for ischemic heart disease who underwent 123I-BMIPP-SPECT, 63 (mean age: 59±12 years) were diagnosed with VA based on invasive coronary angiography and/or clinical examination findings. 123I-BMIPP-SPECT parameters, such as extent and severity scores and washout rate (WR), were calculated using 123I-BMIPP-SPECT data. A multivariate logistic regression model was then used to determine the correlation between 123I-BMIPP-SPECT parameters and major adverse cardiac events (MACEs), including cardiac death, defined as death caused by heart failure (HF), acute myocardial infarction, lethal ventricular arrhythmias, or other definitive cardiac disorders; cardiovascular events (nonfatal acute myocardial infarction, unstable angina pectoris, and arrhythmia requiring hospitalization); and severe HF requiring hospitalization and implantable cardioverter-defibrillator treatment. Results: Total 16 out of the 63 patients have reportedly experienced MACEs. Moreover, our results showed that a higher 123I-BMIPP WR was associated with an increased incidence of MACEs (odds ratio: 5.105, 95% confidence interval 1.503-17.344, p = 0.009). Conclusions: The findings of this current study show that 123I-BMIPP-SPECT WR may be associated with the clinical incidence of cardiac risk in patients with VA.
Ishida et al. (Tue,) conducted a cohort in Vasospastic Angina (n=104). 123I-BMIPP SPECT was evaluated on Major adverse cardiac events (MACEs) (OR 1.13, 95% CI 1.01-1.26, p=0.03). A higher 123I-BMIPP SPECT washout rate was significantly associated with an increased incidence of major adverse cardiac events (OR 1.13) in patients with vasospastic angina.