We report a rare case of sporadic lymphangioleiomyomatosis (LAM) in a 51-year-old male patient presenting with pneumothorax. High-resolution CT revealed multiple thin-walled cysts throughout both lungs. A history of renal angiomyolipoma and histopathologic findings confirmed the diagnosis. Immunohistochemical staining was positive for HMB-45 and α-smooth muscle actin. This case underscores the importance of including sporadic LAM in the differential diagnosis of cystic lung disease in men, despite its rarity. Early radiologic recognition and tissue confirmation are essential for accurate diagnosis and appropriate management.
Nakamura et al. (Tue,) studied this question.