Hypertension has been considered a prevalent cardiovascular disorder and remains a significant public health concern worldwide. Despite advancements in pharmacotherapy, challenges persist in achieving optimal drug delivery and efficacy, as well as potential adverse effects. Nanomedicine offers a promising approach for revolutionizing drug delivery strategies, particularly through transdermal routes in hypertension management. It explores the potential of nanotechnology in addressing the limitations of conventional drug delivery systems for antihypertensive drug delivery. Nanoparticles with their controlled physicochemical properties facilitate enhanced drug encapsulation, prolonged circulation, and targeted delivery to specific sites with enhanced therapeutic outcomes. Transdermal delivery enabled by novel carriers such as microneedles, liposomes, micelles, and ethosomes offers several advantages, including non-invasiveness, sustained release kinetics, and avoidance of first-pass metabolism. Additionally, surface modification techniques by different polymers can enhance skin permeation and drug penetration, optimizing therapeutic efficacy. Therefore, the present manuscript highlights the various novel formulation-based approaches for the treatment of hypertension through transdermal drug delivery systems. Furthermore, recent patents have been enlisted.
Bahadur et al. (Fri,) studied this question.
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