Candidozyma auris (Candida auris) is an emerging pathogenic microorganism that is rapidly gaining attention due to outbreaks in health care facilities and its multidrug resistance. Its origin has yet to be determined, but genotypic analyses have pointed toward a simultaneous independent emergence of the different clades, possibly implicating climate change as a major factor in its recent appearance as a fungal pathogen. In 2022, the World Health Organization placed C. auris in the critical priority group as the second greatest fungal threat globally. Due to limited immunological and proteomic studies of C. auris, we sought to elucidate possible virulence mechanisms and identify leading proteins that can be targeted by immunotherapies and new drugs. Using proteomic analysis, we identified 12 lead proteins related to C. auris hydrophobicity and adhesion, implying that these properties are conferred by multiple proteins.
Junior et al. (Thu,) studied this question.