What question did this study set out to answer?

This research aims to improve the hygroscopicity and antibacterial effects of palmatine hydrochloride by developing cocrystals with different phenolic acids.

April 4, 2026New Journal of Chemistry0 citations

Novel Palmatine Hydrochloride-Phenolic Acid Cocrystals: Effects of Different Phenolic Acids on Hygroscopicity Improvement and Antibacterial Activity Enhancement

XZXin-Ru ZhuLinyi University ZLZe LiLinyi University DSDan SunPeople’s Hospital of Rizhao

Key Points

This research aims to improve the hygroscopicity and antibacterial effects of palmatine hydrochloride by developing cocrystals with different phenolic acids.
Synthesis of palmatine hydrochloride-phenolic acid cocrystals
Characterization of cocrystals using spectroscopic techniques
Assessment of hygroscopicity and antibacterial activity of cocrystals
Cocrystals showed reduced hygroscopicity compared to pure palmatine hydrochloride
Different phenolic acids enhanced antibacterial activity to varying degrees
The best-performing cocrystal formulation demonstrated a significant increase in efficacy against bacterial strains

Abstract

To address the problematic hygroscopicity of palmatine chloride (PCl), a pharmaceutically relevant alkaloid, three novel heteromolecular cocrystals of PCl with phenolic acids (ferulic acid FA, vanillic acid VA, syringic acid...

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