Photocaging the C6 Carboxylate of β-Glucuronide Prodrugs Enables Spatiotemporally Controlled Release of Anticancer Agents via a Dual Activation Strategy

Key Points

• The central aim is to improve the release of anticancer drugs from β-glucuronide prodrugs by overcoming cellular uptake and enzyme limitations.
• Developed photocaging techniques for β-glucuronide prodrugs.
• Analyzed the impact of hydrophilicity on cellular uptake.
• Evaluated enzyme levels for effective drug release.
• Demonstrated significant improvement in cellular uptake of anticancer agents.
• Achieved precise control over drug release timing and location.
• Showed enhanced drug efficacy using the dual activation strategy.