Photothermally Triggered Silk Fibroin Microneedles with Coordinated Gallic Acid-Iron Networks for Synergistic Infected Burn Wound Therapy

Key Points

• The aim is to create a novel microneedle patch to combat infected burn wounds with a focus on oxidative stress and inflammation.
• Engineered a silk fibroin microneedle patch with embedded gallic acid-iron networks
• Conducted in vitro testing for biocompatibility and efficacy against infection
• Evaluated the photothermal properties of the patch in response to light exposure
• The microneedle patch significantly reduced bacterial counts in infected burn models
• Demonstrated improved healing rates due to reduced oxidative stress and inflammation
• Achieved effective pain relief and enhanced drug delivery compared to traditional methods