ABSTRACT Sepsis‐related liver injury (SRLI) involves multiple interrelated pathological processes, including excessive inflammation, oxidative imbalance, mitochondrial dysfunction, dysregulated autophagy, and microcirculatory impairment. Increasing evidence indicates that traditional Chinese medicine (TCM)–based interventions, particularly Chinese medicine injections and Chinese medicine monomeric small molecules, modulate multiple interconnected signaling nodes implicated in SRLI. This review systematically synthesizes current experimental and clinical evidence regarding the protective effects of representative TCM injections and Chinese medicine monomeric small molecules in SRLI models. Across LPS‐ and CLP‐based paradigms, these interventions consistently converge on key regulatory modules such as NF‐κB–mediated inflammatory signaling, Nrf2/HO‐1–dependent antioxidant responses, mitochondrial homeostasis, autophagy‐related pathways, and inflammasome activation. Emerging findings suggest that their therapeutic effects are not confined to isolated linear pathways but involve coordinated regulation and functional cross talk among redox balance, inflammatory transcription, metabolic adaptation, and cell‐death programs. Although encouraging mechanistic and preliminary clinical data have been reported, most current evidence is still derived from basic studies or small‐scale clinical investigations. Future research should strengthen pharmacokinetic evaluation, mechanistic validation at the network level, standardized quality control, and high‐quality randomized clinical trials to clarify the translational potential of TCM‐based strategies in SRLI.
Yunsheng et al. (Fri,) studied this question.