What question did this study set out to answer?

This research aims to investigate the relationship between inflammation, aspirin use, and cardiovascular disease risk.

April 3, 1997Open Access

Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men

Key Points

This research aims to investigate the relationship between inflammation, aspirin use, and cardiovascular disease risk.
Analyzed baseline plasma concentrations of C-reactive protein in participants.
Investigation of myocardial infarction and stroke risk in apparently healthy men with and without aspirin use.
Higher baseline C-reactive protein levels predict increased risk of myocardial infarction and stroke.
Aspirin use significantly reduces the risk of a first myocardial infarction, particularly in those with high C-reactive protein levels.

Abstract

The base-line plasma concentration of C-reactive protein predicts the risk of future myocardial infarction and stroke. Moreover, the reduction associated with the use of aspirin in the risk of a first myocardial infarction appears to be directly related to the level of C-reactive protein, raising the possibility that antiinflammatory agents may have clinical benefits in preventing cardiovascular disease.

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