July 1, 2003
View Full PaperSerum Cardiac Troponin and Subclinical Cardiac Status in Pediatric Chronic Renal Failure
Structured PICO
Do serum cTnT and LV contractility identify subclinical cardiac damage in pediatric patients with chronic renal failure?
P
Population
Pediatric patients with chronic renal failure
I
Intervention
Measurement of serum cardiac troponin T (cTnT) and left ventricular (LV) contractility
O
Outcome
Subclinical cardiac damage (indicated by elevated cTnT or low LV contractility)surrogate
Serum cTnT and LV contractility can identify subclinical cardiac damage in pediatric chronic renal failure, potentially guiding early interventions to reduce cardiovascular morbidity.
Abstract
Elevated cTnT levels are not artifactual, but are genuine indicators of cardiomyocyte damage. Cardiac damage, indicated by either elevated cTnT or low LV contractility, is related to uremia, deranged calcium and phosphorus metabolism, and bicarbonate levels. Serum cTnT and LV contractility identify subclinical cardiac damage that could be treated to hopefully reduce cardiovascular morbidity and mortality in this high-risk population.