T-tubule remodeling precedes detectable LV dysfunction and may be a key mechanism driving the transition from compensated hypertrophy to heart failure.
T-tubule remodeling in response to thoracic aortic banding stress begins before echocardiographically detectable LV dysfunction and progresses over the development of overt structural heart disease. LV T-tubule remodeling is closely associated with the severity of cardiac hypertrophy and predicts LV function. Thus, T-tubule remodeling may constitute a key mechanism underlying the transition from compensated hypertrophy to HF.
Sheng et al. (Thu,) studied this question.
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