Pathological proliferation and activation of cardiac fibroblasts in response to pressure overload is not restricted to a specific developmental subset, suggesting common signaling mechanisms.
The cellular expansion of cardiac fibroblasts after transaortic constriction surgery was not restricted to any single developmental subset. The parallel proliferation and activation of a heterogeneous population of fibroblasts on pressure overload could suggest that common signaling mechanisms stimulate their pathological response.
Ali et al. (Sat,) studied this question.