July 24, 2009

Relationship between stroke volume, cardiac output and filling of the heart during tilt

MBMorten Bundgaard‐NielsenUniversity of Copenhagen HSHenrik SørensenUniversity of Copenhagen MDMads K. DalsgaardUniversity of Copenhagen

Structured PICO

How do stroke volume and cardiac output change during head-up and head-down tilt compared to a resting supine position in healthy humans?

Population

healthy humans

Intervention

head-up tilt (HUT) and 90 degrees head-down tilt (HDT)

Comparator

resting, supine position

Outcome

stroke volume (SV), cardiac output (CO), and left ventricular end-diastolic volume (LVEDV)surrogate

Stroke volume and cardiac output are maximal in the supine position and decrease during both head-up tilt and 90-degree head-down tilt, despite increased preload in the latter.

Abstract

This study confirmed that SV and CO are maximal in resting, supine, healthy humans and decrease during HUT. However, 90 degrees HDT was associated with increased LVEDV and induced a reduction in SV.

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