August 24, 2007Open Access

Short-Term Caloric Restriction Induces Accumulation of Myocardial Triglycerides and Decreases Left Ventricular Diastolic Function in Healthy Subjects

Structured PICO

Does short-term caloric restriction alter myocardial triglycerides and left ventricular diastolic function in healthy subjects?

Population

Healthy subjects

Intervention

Short-term caloric restriction (VLCD)

Outcome

Myocardial triglyceride content and left ventricular diastolic functionsurrogate

Short-term caloric restriction in healthy subjects induces physiological accumulation of myocardial triglycerides and decreases left ventricular diastolic function.

Abstract

Short-term VLCD induces accumulation of myocardial triglycerides. In addition, VLCD decreases left ventricular diastolic function, without alterations in myocardial HEP metabolism. This study documents diet-dependent physiological variations in myocardial triglyceride content and diastolic function in healthy subjects.

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Cite This Study

Meer et al. (Fri,) studied this question.

synapsesocial.com/papers/69d573169d980f6498ccb2ac https://doi.org/https://doi.org/10.2337/db07-0768

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