Among community-dwelling adults, the longitudinal age-associated decline in appendicular lean mass was significantly associated with reductions in left ventricular mass (β=0.287, p<0.001), independent of age and sex.
Cohort (n=1,025)
No
Does age-associated decline in skeletal muscle mass correlate with reductions in left ventricular mass and function in community-dwelling aging adults?
There appears to be a skeletal muscle-cardiac axis characterized by parallel declines in skeletal muscle mass and cardiac mass/function that begins in early aging, preceding clinical cardiovascular disease.
Effect estimate: β=0.287
p-value: p=<0.001
Among community-dwelling normative aging adults, age-associated decline in skeletal muscle mass correlated with reductions in LVM and function, independently of age, sex, and hemodynamic loading conditions. Our findings suggest a skeletal muscle-cardiac axis characterized by parallel declines beginning in early aging, preceding cardiovascular disease. Further studies exploring cardiac and skeletal muscle aging-related declines may direct interventions to halt these adverse processes concurrently.
Wong et al. (Mon,) conducted a cohort in Normative aging (n=1,025). Normative aging (Observational) was evaluated on Association between longitudinal rate of change in appendicular lean mass (ALMChange) and left ventricular mass (LVMChange) (β=0.287, p=<0.001). Among community-dwelling adults, the longitudinal age-associated decline in appendicular lean mass was significantly associated with reductions in left ventricular mass (β=0.287, p<0.001), independent of age and sex.