October 21, 2000

Synthesis of Coumarins via Palladium-Catalyzed Carbonylative Annulation of Internal Alkynes by o-Iodophenols

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Abstract

A variety of substituted coumarins have been prepared in good yields by the palladium-catalyzed coupling of o-iodophenols with internal alkynes and 1 atm of carbon monoxide. Unlike most of the previous work on the palladium-catalyzed carbonylation of alkynes, the insertion of the internal alkyne occurs in preference to the insertion of CO.

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Kadnikov et al. (Sat,) studied this question.

synapsesocial.com/papers/69d70b7fa0177bf533ed9a3e https://doi.org/https://doi.org/10.1021/ol0065569

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