August 21, 2013Open Access

Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of Braf V600E–Driven Lung Tumors

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Abstract

The essential autophagy gene Atg7 functions to promote BrafV600E-driven lung tumorigenesis by preserving mitochondrial glutamine metabolism. This suggests that inhibiting autophagy is a novel approach to treating BrafV600E-driven cancers.

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Strohecker et al. (Wed,) studied this question.

synapsesocial.com/papers/69d746d4b1cb92dd1bb8a490 https://doi.org/https://doi.org/10.1158/2159-8290.cd-13-0397

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