In patients with TTNtv-associated DCM, left ventricular reverse remodeling is common and predicts better outcomes, particularly in women, despite a high burden of arrhythmias.
DCM caused by TTNtv presented in midlife and was associated with a high burden of AF and ventricular arrhythmias, which often preceded DCM diagnosis. Furthermore, LVRR occurred in a high proportion of patients and was a strong negative predictor of the composite outcome. Female sex was positively associated with occurrence of LVRR and longer event-free survival.
Vissing et al. (Mon,) studied this question.