September 19, 2014Open Access
View Full PaperBiomarCaRE: rationale and design of the European BiomarCaRE project including 300,000 participants from 13 European countries
Structured PICO
Do established and emerging biomarkers improve cardiovascular risk prediction beyond standard European risk scores in primary and secondary prevention cohorts?
P
Population
Primary and secondary prevention cohorts including over 300,000 participants from 13 European countries
I
Intervention
Established and emerging biomarkers for cardiovascular risk prediction
C
Comparator
Standard European risk scores
O
Outcome
Value of established and emerging biomarkers for cardiovascular risk prediction
The BiomarCaRE project outlines the rationale and design for assessing established and emerging biomarkers for cardiovascular risk prediction in over 300,000 European participants.
Abstract
Biomarkers are considered as tools to enhance cardiovascular risk estimation. However, the value of biomarkers on risk estimation beyond European risk scores, their comparative impact among different European regions and their role towards personalised medicine remains uncertain. Biomarker for Cardiovascular Risk Assessment in Europe (BiomarCaRE) is an European collaborative research project with the primary objective to assess the value of established and emerging biomarkers for cardiovascular risk prediction. BiomarCaRE integrates clinical and epidemiological biomarker research and commercial enterprises throughout Europe to combine innovation in biomarker discovery for cardiovascular disease prediction with consecutive validation of biomarker effectiveness in large, well-defined primary and secondary prevention cohorts including over 300,000 participants from 13 European countries. Results from this study will contribute to improved cardiovascular risk prediction across different European populations. The present publication describes the rationale and design of the BiomarCaRE project.