MMP-9 is identified as a key mediator of age-related cardiac inflammation, driving macrophage polarization, fibrosis, and diastolic dysfunction.
Our results define the cardiac ageing inflammatory signature and assign MMP-9 roles in mediating the inflammaging profile by indirectly and directly modifying macrophage polarization. Our results explain early mechanisms that stimulate ageing-induced cardiac fibrosis and diastolic dysfunction.
Ma et al. (Wed,) studied this question.
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