July 4, 2014Open Access

Echinomycin protects mice against relapsed acute myeloid leukemia without adverse effect on hematopoietic stem cells

YWYin WangShanghai Mental Health Center YLYan LiuShenyang Pharmaceutical University FTFei TangWannan Medical College

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Abstract

Key Points Echinomycin can selectively kill the leukemia-initiating cell in relapsed AML without normal stem cell toxicity. In vivo delivery of echinomycin can induce long-term complete remission in a murine model of relapsed AML.

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Wang et al. (Fri,) studied this question.

synapsesocial.com/papers/69d7e4f6f39344339dd18c65 https://doi.org/https://doi.org/10.1182/blood-2013-12-544221

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