Validating novel tau positron emission tomography tracer F‐18‐AV‐1451 (T807) on postmortem brain tissue

Our data suggest that F-18-AV-1451 holds promise as a surrogate marker for the detection of brain tau pathology in the form of tangles and paired helical filament-tau-containing neurites in Alzheimer brains but also point to its relatively lower affinity for lesions primarily made of straight tau filaments in non-Alzheimer tauopathy cases and to the existence of some F-18-AV-1451 off-target binding. These findings provide important insights for interpreting in vivo patterns of F-18-AV-1451 retention.