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In this work, we have developed a novel green nanoparticle platform based on lignin without chemical modification. The alkali lignin (AL) was used to prepare nanoparticles with perfect spheres and well dispersibility via a simple self-assembly method by adding water to a methanol solution of AL. Finally, we showed that self-assembly of AL with the bioactive molecule resveratrol (RSV) and Fe3O4 magnetic nanoparticles led to the formation of stable nanodrug carrier. In cytological and animal tests, the magnetic RSV-loaded lignin nanoparticles (AL/RSV/Fe3O4 NPs) demonstrated good anticancer effects and enhanced in vitro RSV release and stability, drug accumulation, and better tumor reduction, as well lower adverse effects than free drugs, strongly supporting the AL NPs application as a new and highly efficient nanodelivery. Moreover, this renewable green material with its simple preparation technique and easy large-scale production would be a highly potential candidate for many poorly soluble drugs.
Dai et al. (2017) studied this question.