Elevated amyloid‐ß and tau burden is associated with accelerated cognitive decline on a digital clock drawing test in preclinical AD

Our results suggest that longitudinal decline in DCTclock performance, especially in information processing or executive function, is related to early Aß/tau burden in older CN adults. Diminished longitudinal DCTclock performance, especially in latency features uniquely captured by digital tools, may reflect greater cognitive efforts in preclinical AD.